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Source and full article Illumina and bioMerieux agreed to collaborate in the development of applications for microbiology sequencing technologies. Initially, the partners seek to develop a next-generation sequencing epidemiology solution designed to be used in the monitoring and control of bacterial infections.

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Source and full article AMSTERDAM (Reuters) – A second Dutch farm was hit by an outbreak of bird flu, the government said on Thursday, prompting the destruction of 43,000 chickens and prolonging restrictions on trade in the world’s

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Source and full article Thus, our study demonstrates that antiviral treatment affects the development of the adaptive immune response and protective immunity against influenza.—Marois, I., Cloutier, A., Garneau, É., Lesur, O., Richter, M. V. The administration of oseltamivir results in reduced effector and memory CD8+ T cell responses to influenza and affects protective immunity.

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Source and full article The emergence of new sequencing technologies has facilitated the use of bacterial whole genome alignments for evolutionary studies and outbreak analyses. These datasets, of increasing size, often include examples of multiple different mechanisms of horizontal sequence transfer resulting in substantial alterations to prokaryotic chromosomes. The impact of these processes demands rapid and flexible approaches able to account for recombination when reconstructing isolates’ recent diversification. Gubbins is an iterative algorithm that uses spatial scanning statistics to identify loci containing elevated densities of base substitutions suggestive of horizontal sequence transfer while concurrently constructing a maximum likelihood phylogeny based on the putative point mutations outside these regions of high sequence diversity.

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Source and full article We provide the first scientific report of influenza A virus involvement in a mass mortality event among harbour seals (Phoca vitulina) off the west coast of Sweden. Avian influenza A (H10N7) virus was detected in the lungs of two affected animals. This subtype has not been reported in seals to date, nor has influenza A-associated mortality been reported in seals in Europe. Circulation of avian influenza viruses in mammals may have implications for public health.

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Source and full article We believe that it is important to develop vaccines against equine influenza viruses in the event that an EIV evolves, adapts and spreads in humans causing disease. We generated a live attenuated H3N8 vaccine candidate and demonstrated that the vaccine was immunogenic and protected mice and ferrets against homologous and heterologous EIV.

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Source and full article Neuraminidase inhibitors are widely prescribed for the treatment of influenza. Observational studies have reported that oseltamivir significantly lowers respiratory tract complications and the likelihood of hospitalisation, while an industry-sponsored systematic review of randomised controlled trials (RCTs) concluded that oseltamivir reduced the likelihood of complications requiring an antibiotic.1 ,2 However, many clinical trials of oseltamivir and zanamivir were never published. The current review was performed to examine all the published and unpublished data.

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Questions and Answers on Highly Pathogenic H5N8 Avian influenza strain: OIE – World Organisation for Animal Health

November 20, 2014

Source and full article This virus was detected early this year in Asia in poultry species in the Republic of Korea, Japan and in China. In January 2014, the authorities of the Republic of Korea reported the first poultry cases of disease due to the infection with a highly pathogenic strain H5N8 of avian influenza […]

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H5N8 Seqs In England Match Germany & Netherlands

November 19, 2014

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What Our Sewage Can Teach Us About Infections – NYTimes.com

November 19, 2014

Source and full article If her team could sample sewage from every neighborhood in the metro area, Dr. Carlton reasoned, the resulting genetic map would highlight the city’s microbial diversity across different districts. Once public health officials knew what normal bacteria and viruses to expect in each sector of the city, she hopes, they will […]

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WHO Notified of Three Cases of Human Infection with H7N9 Virus in China – Infection Control Today

November 19, 2014

Source and full article On Nov. 15, 2014, the National Health and Family Planning Commission (NHFPC) of China notified the World Health Organization (WHO) of three additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus, including one …

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Bird flu restrictions to remain in force for ‘at least’ 30 days – Farmers Guardian

November 19, 2014

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Experimentally infected domestic ducks show efficient transmission of Indonesian H5N1 highly pathogenic avian influenza virus, but lack persistent viral shedding.

November 19, 2014

Source and full article Clinical disease was more frequent and more severe in contact-infected (2 of 5) than inoculation-infected ducks (1 of 15). We conclude that Indonesian clade 2.1 H5N1 highly pathogenic avian influenza virus does not persist in individual ducks after acute infection.

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Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice.

November 19, 2014

Source and full article In conclusion, TLR3 worsens the pathogenesis of H5N1 infection but not of pH1N1 infection, highlighting the differences in the pathogenesis of these two viruses and the different roles of TLR3 in their pathogenesis.

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Social capital and immunization against the 2009 A(H1N1) pandemic in the American States.

November 19, 2014

Source and full article Results show that Social capital was strongly correlated with 2009 A(H1N1) immunization acceptance among American States. In a multivariate regression analysis, the association remains strong and significant also when controlling state-level confounders. In conclusion, social capital, at least in a U.S. context, is shown to be associated with the state-level uptake […]

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The Reliability of Tweets as a Supplementary Method of Seasonal Influenza Surveillance.

November 19, 2014

Source and full article Compared to tweet analyses in the previous influenza season, this study demonstrated increased accuracy in using Twitter as a supplementary surveillance tool for influenza as better filtering and classification methods yielded higher correlations for the 2013-2014 influenza season than those found for tweets in the previous influenza season, where emergency department […]

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Gut microbiota: a natural adjuvant for vaccination.

November 19, 2014

Source and full article In this issue of Immunity, Oh et al. (2014) reveal an unappreciated facet of how the microbiota influences immune responses. Immunity to nonadjuvanted vaccines depends on Toll-like-receptor-5-mediated sensing of the microbiota.

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