Source and full article H5, H7, and H9 avian influenza viruses represent the top three subtypes that are candidates to cause the next human influenza pandemic

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Source and full article This chapter summarizes recent discoveries on the genetic and phenotypic traits required for avian influenza viruses to become airborne transmissible between mammals.

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Source and full article These results suggest that the PBM in the NS1 protein may determine viral persistence in the human and avian IAV interface.

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Source and full article This study demonstrates the value of using in-silico structural modelling approaches to complement physical studies in characterization of new influenza viruses.

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Source and full article Taipei, July 23 (CNA) Taiwan’s Mainland Affairs Council (MAC) withdrew a yellow travel advisory for Guangdong Province in southern China Wednesday, after health authorities lowered an H7N9 epidemic alert for that area. In a statement, the council said …

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Source and full article
Phase II-sponsored efforts will focus on a version of Titer on Chip that can be used to determine the potency of vaccines developed against potential pandemic viruses, including the deadly avian H5N1 and H7N9 viruses. Flu-ToC utilizes a panel of …

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Source and full article Here, we demonstrate that an early virus isolate from the recent A(H7N9) outbreak in Eastern China replicated as efficiently as human-adapted IAV in explanted human lung tissue,

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Source and full article We clearly show that chickens, but not pigeons, are highly permissive hosts of both H7 viruses, allowing high-titer replication and virus shedding without any relevant clinical signs.

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Source and full article One strategy to try to prevent that from happening is limiting the number of humans that are exposed to these variant viruses, depriving the virus of opportunities to adapt to human physiology. To that end, the CDC has issued the following advice for those planning to visit the fair:

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Source and full article The page below is a very early first play with H7N9. It’s just detections broken across 2013 and 2014, by province most likely to have been the source of the infections (as far as I can tell) in mainland China. 

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Shanghai authorities deny H7N9 doctor death rumour

July 22, 2014

Source and full article involved in the rescue were in quarantine." Shanghai municipal public health planning Commission official micro-blog today to deny the rumor: the news as a rumor and said "Shanghai did not take place in the near future of H7N9 avian flu cases in humans, and no deaths." Health authorities also warned, don’t […]

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Structure of Influenza Virus N7: the Last Piece of the Neuraminidase “Jigsaw” Puzzle

July 22, 2014

Source and full article . Crystal structures for all of these proteins have been solved and reported with the exception of N7 and N6. The structural analysis of influenza virus N7 and N6 presented in this study therefore completes the puzzle and adds to a comprehensive understanding of influenza virus NA.

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Bird Migration and Avian Influenza: A Comparison of Hydrogen Stable Isotopes and Satellite Tracking Methods.

July 22, 2014

Source and full article In the absence of feather based-isoscapes, we recommend a combination of isotope analysis and satellite-tracking as the best means of generating aggregate movement data for informing disease models.

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The compatibility of of human H7N9 virus and circulating human influenza subtypes.

July 22, 2014

Source and full article Our results demonstrate that some reassortant vRNPs with subunits derived from the H7N9 and other human viruses can have much higher polymerase activities than the wild-type levels.

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Molecular epidemiology of H9N2 influenza viruses in Northern Europe.

July 22, 2014

Source and full article Nucleotide sequence comparison and phylogenetic analyses indicate that H9N2 was transmitted from wild birds to reared birds in 2010, and that highly identical strains have been circulating in Europe during the last few years.

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Perpetuation and reassortment of gull influenza A viruses in Atlantic North America.

July 22, 2014

Source and full article Gulls are important hosts of avian influenza A viruses (AIVs) and gull AIVs often contain gene segments of mixed geographic and host lineage origins. In this study, the prevalence of AIV in gulls of Newfoundland, Canada from 2008 to 2011 was analyzed.

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6 H7N9 treatments identified

July 22, 2014

Source and full article In a novel discovery, scientists have identified six potential therapeutics to treat the deadly H7N9 avian influenza.

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Potential new flu drugs target immune response, not virus

July 22, 2014

Source and full article "We set out to characterize the response to the severe disease-causing H7N9 virus and compare it to responses elicited by other serious flu viruses in a mouse model of infection," says Morrison. That work involved determining which genes are turned on …

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The Hajj as an influenza vector

July 21, 2014

Source and full article One third (29.8%) of the participants acquired ≥1 virus, particularly rhinovirus (14.0%), coronavirus E229 (12.4%), and influenza A(H3N2) virus (6.2%) while in Saudi Arabia. None of the participants were positive for the Middle East respiratory syndrome coronavirus. In addition, 50.0% and 62.0% of pre-Hajj and post-Hajj specimens, respectively, were positive for […]

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Ultimatum to health-care workers: get the flu shot, or wear a mask

July 21, 2014

Source and full article The vast majority continue to have voluntary policies that have consistently produced staff influenza vaccination rates well below public health targets.

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