Source and full article At baseline, the seroprevalence of anti-A(H5N1) antibodies (titer, ≥80) among exposed individuals was 2% significantly higher than that among the controls (0%). Having chronic lung disease was a significant risk factor for infection. Antibodies against A(H9N2) were not detected at baseline when A(H9N2) was not circulating in poultry. At follow-up, A(H9N2) was detected in poultry, and consequently, the seroprevalence among exposed humans was between 5.6% and 7.5%. Vaccination of poultry, older age, and exposure to ducks were risk factors for A(H9N2) infection.

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Source and full article These data indicate that a non-adjuvanted, whole-virus H9N2 vaccine is well-tolerated and immunogenic in healthy adults.

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Source and full article Curiously ignored, however, is evidence that calls into question A(H5N1) viral doomsday scenarios; for example, after countless people (certainly at least hundreds of thousands, if not millions) have been intimately exposed to A(H5N1) in poultry epizootics and live bird markets, almost none have been recognized as having mild infections, very few have A(H5N1) antibody at all, and, when detected, the antibody level is typically low and transient

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Source and full article The intermingling of wild birds, ducks, and poultry over the past two decades have produced dozens of new clades of avian flu viruses that could potentially endanger humans, including subtypes H5N1, H7N9, H10N8, and H9N2 (see EID Journal: Predicting …

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Source and full article Unprotected animals that were mock vaccinated or received empty vector developed interstitial pneumonia characterized by a marked alveolitis, accompanied by loss of appetite, weight loss, and heavy breathing. In contrast, animals vaccinated with MVA-H7-Sh2 were protected from severe disease.

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Source and full article Considered an epicenter of pandemic influenza virus generation, southern China has recently seen an increasing number of human H7N9 infections. However, it is not the only threat. On 30 November 2013, a human H10N8 infection case was first described …

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Source and full article Through a (pre)pandemic preparedness contract with HHS, Novartis also funded efforts to develop a vaccine using synthetic genomics for H7N9, a strain of avian flu that emerged in China early last year. The US government ordered a stockpile of the …

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Source and full article Us government ban on research into enhanced pathogens also affects flu surveillance and vaccine work. Sara Reardon. 23 October 2014. Article tools. Rights & Permissions. Alfred Pasieka/SPL. The H7N9 influenza virus is used in the type of research that …

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Source and full article The respiratory infection ability was about 40 times more effective than gastrointestinal infection, which suggested that urgent attention should be paid to environmental disinfection to block airborne transmission of influenza virus

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Source and full article The 4 recombinant viruses rescued using reverse genetics meet the criteria for classification of low pathogenic avian influenza strains, thus supporting the use of them for the development of seeds and production of pre-pandemic vaccines.

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Vaccines for pandemics.

October 26, 2014

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Margaret McCartney: What use is mass flu vaccination? | The BMJ

October 25, 2014

Source and full article For each healthy adult, a Cochrane review found that vaccination saved an average of just 0.04 days off work and concluded that no evidence supported it as a routine public health measure.5 And among over 65s, Cochrane reviews found only poor quality data and were unable to draw conclusions of any […]

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Taiwan raises travel alert for Beijing, Xinjiang on H7N9 reports | Culture | FOCUS TAIWAN – CNA ENGLISH NEWS

October 25, 2014

Source and full article Taiwan’s Mainland Affairs Council (MAC) raised its travel alert for Beijing and the Xinjiang Uyghur Autonomous Region in China Sunday after two human infections of H7N9 avian flu were reported there.

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Performance of Rapid Influenza Diagnostic Test in an outbreak setting

October 25, 2014

Source and full article CONCLUSIONS: Due to high specificity, RIDTs can play a role in screening for influenza in outbreaks and instituting antiviral therapy in a timely manner when positive. RIDTs can also be useful in remote settings where molecular virology testing is not easily accessible. Suboptimal sensitivity of RIDTs can be addressed by use […]

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Broad Protection against Avian Influenza Virus by Using a Modified Vaccinia Ankara Virus Expressing a Mosaic Hemagglutinin Gene

October 25, 2014

Source and full article These studies demonstrated that a mosaic influenza virus H5 hemagglutinin expressed by a viral vector can elicit full protection against diverse H5N1 challenges as well as induce broader immunity than a wild-type hemagglutinin.

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Virulence Determinants in the PB2 Gene 1 of a Mouse-Adapted H9N2 Virus.

October 24, 2014

Source and full article . Therefore, we defined a novel pathogenic determinant, providing further insights into the pathogenesis of influenza viruses in mammals.

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Influenza Outbreak in a Vaccinated Population – USS Ardent, February 2014.

October 24, 2014

Source and full article This outbreak highlights the risk for an H3N2 influenza outbreak among vaccinated and otherwise healthy young persons.

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Human Co-Infection with Avian and Seasonal Influenza Viruses, China.

October 24, 2014

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Poultry Market Closures and Human Infection with Influenza A(H7N9) Virus, China, 2013-14.

October 24, 2014

Source and full article Closure of live poultry markets was implemented in areas affected by the influenza virus A(H7N9) outbreak in China during winter, 2013-14. Our analysis showed that closing live poultry markets in the most affected cities of Guangdong and Zhejiang provinces was highly effective in reducing the risk for H7N9 infection in humans.

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Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness.

October 24, 2014

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