Source and full article Guangdong Provincial Health and Family Planning Commission April 20 briefing, Shantou City, reported a new confirmed case of H7N9 avian influenza infection.

The case is a female, 55 years old, [Wang], Shantou City. Confirmed on April 19, currently in critical condition in a Shantou city hospital.

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Source and full article Our approach offers a means of estimating willingness to pay for search costs associated with targeted vaccination of superspreaders, which can inform policies regarding whether a targeted intervention should be implemented and, if so, up to what levels.

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Source and full article CONCLUSIONS: In formulating effective communication strategies, the first step is to define the goal of a vaccination program. We recommend implementing conceptual elements from the most current theoretical literature when planning communication strategies and increasing organizational involvement in implementing guidelines in future health crises. (Disaster Med Public Health Preparedness. 2014;x:1-12).

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Source and full article Farmers could be among the first people to be infected with a novel reassortant virus in a pig herd and may serve as a source of the virus for their communities. In this study, the pig production systems of smallholders in rural Thailand were examined to qualitatively evaluate the potential risks that may contribute to the spread of influenza A viruses

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Source and full article The health literacy level remains low among the general population in Beijing and the extent of relativities in knowledge, behavior, and skill about influenza was found to be weak.

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Source and full article Scientific evidence points to a connection between the conditions at these live markets and the spread of flu, suggesting that until other means are found to prevent the transmission of or effectively treat the illness, China must shut down live poultry markets to prevent further spread of the virus and a possible global pandemic.

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Source and full article One more human H7N9 case has been confirmed in east China’s Jiangsu Province, the provincial health department said on Saturday. A 35-year-old woman surnamed Lu, who was confirmed to have the infection on Saturday, is in critical condition, according …

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Source and full article Scottish and American scientists have found a new way to prevent flu infections that could, in theory, be used to fight an epidemic long before a vaccine is ready.

The method, successfully tested only in mice thus far, is a nasal spray of engineered proteins that coat the receptors in the nose and throat to which flu viruses attach.

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Source and full article Monitoring Wikipedia hits could help researchers determine how many people have been affected by the flu.

A research team developed a method for estimating how high influenza levels are in the U.S. by monitoring the amount of traffic on certain flu-related Wikipedia pages, a PLOS news release reported.

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Source and full article . We found that for subjects starting oseltamivir during the influenza incubation period, the risk of resistance emergence is dramatically increased. Thus, our findings suggest that standard prophylaxis should only be used after exclusion of an influenza infection in the incubation period by use of a rapid test.

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China reports 2 H7N9 cases, 1 fatal

April 18, 2014

Source and full article Two new H7N9 avian flu cases, one of them fatal, were reported by two of China’s provinces today. Health officials in Anhui province announced that a 70-year-old man had died of the infection, according to a post today from FluTrackers, an online infectious disease message board.

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Two Outbreaks of High-path Avian Flu in North Korea – The Poultry Site

April 18, 2014

Source and full article NORTH KOREA – Two outbreaks of H5N1 highly pathogenic avian influenza (HPAI) in poultry have been reported in the P’yongyang region. The North Korean veterinary authority sent an Immediate Notification dated 16 April to the World Organisation for Animal Health (OIE).

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Serologic assay for avian-origin influenza A (H7N9) virus in adults of Shanghai, Guangzhou and Yunnan, China

April 18, 2014

Source and full article Low levels of protective immunity pre-existed in some general adult population of the three areas, and pre-existing immunity against H7N9 in Guangzhou appears stronger than that in Shanghai and Yunnan.

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Homosubtypic and heterosubtypic antibodies against highly pathogenic avian influenza H5N1 recombinant proteins in H5N1 survivors and non-H5N1 subjects.

April 17, 2014

Source and full article Although all 28 non-H5N1 subjects had no neutralizing antibodies against H5N1 virus, they did have cross-reactive antibodies to those five recombinant proteins. A significant increase in cross-reactive antibody titer to rVac-H5 HA and rVac-NA was found in paired blood samples from patients infected with the 2009 pandemic virus.

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Comparison of behaviors regarding live poultry exposure among rural residents in Vietnam and Thailand.

April 17, 2014

Source and full article CONCLUSION: The findings suggest important roles of economic imperatives and cultural preference for live poultry for consumption in supporting poultry rearing and live poultry purchase among rural residents.

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Cytokine Storm Plays a Direct Role in the Morbidity and Mortality from Influenza Virus Infection and is Chemically Treatable with a Single Sphingosine-1-Phosphate Agonist Molecule.

April 17, 2014

Source and full article This chapter visits primarily influenza virus infection and resultant cytokine storm. It provides the compelling evidence that illuminates cytokine storm in influenza pathogenesis and the clear findings that cytokine storm is chemically tractable by therapy directed toward sphingosine-1-phosphate receptor (S1PR) modulation, specifically S1P1R agonist therapy. The mechanism(s) of how S1P1R signaling […]

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Novel oral anti-influenza drug candidate AV5080.

April 17, 2014

Source and full article CONCLUSIONS: Based on the results presented in this study, AV5080 is a promising novel oral drug candidate for the treatment of influenza, including oseltamivir-resistant types. Further pre-clinical development of AV5080 is warranted.

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Community studies of influenza: new knowledge, new questions.

April 17, 2014

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Changing social contact patterns under tropical weather conditions relevant for the spread of infectious diseases.

April 17, 2014

Source and full article Frequent social contacts on weekdays and under good weather conditions, including high temperature and low absolute humidity, all might facilitate the transmission of infectious diseases in tropical regions.

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Universal biosensor for detection of influenza virus.

April 17, 2014

Source and full article Application of universal anti-M1 antibodies allows detection of all serotypes of influenza A virus. The simple design of the sensor facilitates miniaturization of the device and its implementation for routine diagnostics during first contact with the patient, before applying a proper treatment.

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